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Glenda Halliday

Prof Glenda Halliday BSc(Hons), PhD

Current Appointments

NHMRC Principal Research Fellow, Prince of Wales Medical Research Institute
Conjoint Professor, School of Medical Sciences, University of New South Wales
Honorary Visiting Scientist, Westmead Hospital, Concord Hospital

Current Projects

Alzheimer’s disease and dementia with Lewy bodies. How different are they? - NHMRC  2004-2006
Understanding the variations in frontotemporal dementia - NHMRC 2004-2006

Targeting the inflammatory mechanisms in Alzheimer's disease - NHMRC 2004-2006

The Australian Parkinson's Project - Uncovering genetic risk factors for sporadic Parkinson's disease - NHMRC 2006-2008

Isoprenoids, neuromelanin and neuronal vulnerability in Parkinson's disease - NHMRC 2006-2008

Research Staff

Academic Researchers:
Olivier Piguet, BPsych, MAHons, PhD, NHMRC Neil Hamilton Fairley Fellow

Claire Shepherd, BScHons, PhD, NHMRC Senior Research Officer

Wayne Reid, BAHons, MPsych, PhD, Senior Research Officer

Yue Huang, BM, MSc, PhD, NHMRC Research Officer

Other Research Support Staff:
Heather McCann, BMedSci(Path),DipHealthSci(Pod), Senior Research Assistant

Heidi Cartwright, BSc, Computer Illustrator

Michael Cartwright, BSc, MSc, Database Manager

Karen Murphy, BScHons, Research Assistant

Julia Stevens, BScHons, Research Assistant

Research Students

Postgraduate Students:

Vanessa Young, MBBS,BScMed - Neurpathological correlates of white matter hyperintensities

Daniel Brooks, BScHons – Pathological correlates of cognition

Linda Truong, BScHons - Role of the caudal intralaminar nuclei of the thalamus in Parkinson's disease

Stephen Duma, BSc, MSc - Is extrapyramidal motor slowing a frontal executive function?

Christine Song, BScHons - The Staging and severity of multiple system atrophy

Lolita Warden, BScHons - The role of inflammation in Alzheimer's disease

Raymond Schwarz, MBBS, FRACP - A clinical and pathological study of small vessel cerebrovascular disease in Parkinsonism

Undergraduate Students:

Anna Sokolova - Inflammatory mediators in presenelin-1 Alzheimer's disease

Alex Owen - Determining if there are any pathological differences between genetic and sporadic forms of Parkinson's disease

Key Publications

In Parkinson’s disease
Halliday GM, Ophof A, Broe M, Jensen PH, Kettle E, Fedorow HS, Cartwright MI, Griffiths FM, Shepherd CE, Double KL (2005) a-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson’s disease. Brain 128:2654-2664.

Kwok JBJ, Hallupp M, Loy C, Chan DKY, Woo J, Mellick GD, Buchanan DD, Silburn PA, Halliday GM, Schofield PR (2005) GSK3b polymorphisms alter transcription and splicing in Parkinson’s disease. Ann. Neurol. 58:829-839.

Orr CF, Rowe DB, Mizuno Y, Mori H, Halliday GM (2005) A possible role for humoral immunity in the pathogenesis of Parkinson’s disease. Brain 128:2665-2674.

Huang Y, Hayes M, Harding AJ, Brooks WS, Fung VSC, Rowe D, Joffe R, Crimmins D, Hely M, Halliday GM (2006) Genetic anticipation in familial Parkinson’s disease without SCA gene mutations. Parkinsonism & Related Disorders 12:309-313.

In progressive supranuclear palsy

Cordato NJ, Duggins AJ, Halliday GM, Morris JGL, Pantelis C (2005) Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy. Brain 128:1259-1266.

Halliday GM, Macdonald V, Henderson JM (2005) A comparison of degeneration in the motor thalamus and cortex between progressive supranuclear palsy and Parkinson’s disease. Brain 128:2272-2280.

Schofield EC, Caine D, Kril JJ, Cordato NJ, Halliday GM (2005) Staging disease severity in movement disorder tauopathies: brain atrophy separates progressive supranuclear palsy from corticobasal degeneration. Mov. Disord. 20:34-39.

Cordato NJ, Halliday GM, Caine D, Morris JGL (2006) Comparison of motor, cognitive and behavioural features in progressive supranuclear palsy and Parkinson’s disease. Mov. Disord. 21:632-638.

In frontotemporal dementia
Davies RR, Hodges JR, Kril JJ, Patterson K, Halliday GM, Xuereb JH (2005) The pathological basis of semantic dementia. Brain 128:1984-1995.

Graham A, Davies R, Xuereb J, Halliday G, Kril J, Creasey H, Graham K, Hodges J (2005) Pathologically proven frontotemporal dementia presenting with severe amnesia. Brain 128:597-605.

Kril JJ, Macdonald V, Patel S, Png F, Halliday GM (2005) Distribution of brain atrophy in behavioural variant frontotemporal dementia. J. Neurol. Sci. 232:83-90.

Kersaitis C, Halliday GM, Xeureb JH, Pamphlett RS, Hodges JR, Kril JJ (2006) Ubiquitin-positive inclusions and progression of pathology in frontotemporal dementia and motor neuron disease identifies a case group with mainly early pathology. Neuropathol. Appl. Neurobiol. 32:83-91.

In dementia with Lewy bodies & Alzheimer’s disease

McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda J, Lippa C, Perry EK, Aarsland D, Arai H, Ballard GC, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz C, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria R, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee V, Lees A, Litvan I, Londos E, Lopez O, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska E, Pasquier F, Perry RH, Schulz J, Trojanowski J, Yamada M, for the Consortium on DLB (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65:1863-1872.

Halliday GM, Song YJC, Lepar G, Brooks WS, Kwok JB, Kersaitis C, Gregory G, Shepherd CE, Rahimi F, Schofield PR, Kril JJ (2005) Pick bodies in a family with presenilin-1 Alzheimer’s disease. Ann. Neurol. 57:139-143.

Shepherd CE, Gregory GC, Vickers JC, Halliday GM (2005) Novel ‘inflammatory plaque’ pathology in presenilin-1 Alzheimer’s disease. Neuropathol. Appl. Neurobiol. 31:503-511.

Gregory GC, Macdonald V, Schofield PR, Kril JJ, Halliday GM (2006) Differences in regional brain atrophy in genetic forms of Alzheimer’s disease. Neurobiol. Aging 27:387-93.

Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zola P, Arima K, Iseki E, Murayama S, Kretzchmar H, Neumann M, Lippa C, Halliday G, MacKenzie J, Khan N, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Mann DMA (2006) Comparison of the extent of tau pathology in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onsetAlzheimer’s disease. Neuropathol. Appl. Neurobiol. 32:374-387.