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Matthew Kiernan
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A/Prof Matthew KIERNAN, MBBS(Hons), PhD, FRACP |
Personal history
Matthew
completed his PhD at POWMRI in 1997 and was awarded NHMRC CJ
Martin and RG Menzies Fellowships to work with Prof. Hugh
Bostock FRS in London. He returned to Sydney in 2001 to take
up his current positions at UNSW and POWMRI.
Current Appointments
ASSOCIATE PROFESSOR IN NEUROLOGY,
Prince of Wales Clinical School, Faculty of
Medicine, UNSW
SENIOR SCIENTIST,
Prince of Wales Medical Research Institute
CONSULTANT NEUROLOGIST,
Institute of Neurological Sciences, Prince of Wales Hospital
CONSULTANT, Sleep Disorders Unit, Prince of Wales
Hospital
CONSULTANT
NEUROLOGIST/CLINICAL NEUROPHYSIOLOGIST,
Sydney Children’s Hospital
Current Projects
“Resurgent” Na+ currents and post-ischaemic
paraesthesiae (ARC Discovery Grant)
Mechanisms of chemotherapy induced neurotoxicity (NHMRC Project
Grant)
Nerve excitability in spinal cord injury patients
(NSW
Ministry for Science and Medical Research; Spinal Cord Injury &
Related Neurological Conditions Research Program Grant).
Patterns of neuronal degeneration in motor
neurone disease (NSW
Ministry for Science and Medical Research; Spinal Cord Injury &
Related Neurological Conditions Research Project Grant).
Site of origin of motor neurone disease (MND
Research Institute of Australia)
Pathophysiology of uraemic neuropathy
Nocturnal hypoventilation in motor neurone disease
Effects of toxins on impulse transmission (tetrodotoxin/puffer
fish poisoning)
Role of inherited mutations of neuronal
Na+
channels in
epileptic patients
Research Staff
Dr Robert Boland
BAppSc (Phty), PhD – Post-doctoral Fellow (NSW Ministry for
Science and Medical Research)
Dr Arun
Krishnan PhD FRACP – Post-doctoral fellow (UNSW Dean's
Postdoctoral Fellowship)
Dr Cindy Lin MEng Sci, PhD -
Post-doctoral
fellow (NHRMC CJ Martin Fellowship)
Ms Louise Trevillion BSc – Research Officer (in
collaboration with University of Sydney)
Mr Tim Howells BSc – Research Officer (in
collaboration with University of Sydney)
Sr Margie Zoing BN – Research Assistant
Research Students
Dr
Steve Vucic (PhD) - Site of origin and patterns of neuronal
degeneration in motor neurone disease (MND Research Institute of
Australia Clinical Fellow)
Mr Eric Han (PhD) – Neurophysiology of peripheral
nerves under mechanical loading in normal humans and carpal
tunnel syndrome patients (with
A/Prof Lynne Bilston; Prince of Wales Clinical School
Scholarship)
Ms Susanna Park (PhD) – Chemotherapy-induced
neurotoxicity (Australian Postgraduate Award)
Ms Jennica Winhammar (PhD) – Mechanisms of
nocturnal hypoventilation in motor neurone disease (with Dr
Dominic Rowe; Rotary Scholarship)
Ms S Rosengren
(Co-supervisor for PhD with A/Prof James Colebatch).
Key Publications in 2005
1.
Isbister GK, Kiernan MC. (2005). Neurotoxic marine poisoning.
Lancet Neurology 4:219-228 (Invited review).
2.
Kalapesi, F., Krishnan, A.V., Kiernan, M.C. (2005). Segmental
facial anhidrosis and tonic pupils with preserved deep tendon
reflexes: a novel autonomic neuropathy. Journal of
Neuro-ophthalmology 25:5-9.
3.
Kiernan MC. (2005). Riluzole: a glimmer of hope in the treatment
of motor neurone disease. Med J Aust 182:319-20. (Invited
editorial).
4.
Kiernan MC, Isbister, G.K., Lin, C.S., Burke, D., Bostock, H.
(2005). Acute tetrodotoxin-induced neurotoxicity following
ingestion of puffer fish. Ann Neurol 57:339-48.
5.
Kiernan M.C., Krishnan A.V., Lin, C.S., Burke, D., Berkovic, S.
(2005). Mutation in the Na+ channel subunit SCN1B
produces paradoxical changes in peripheral nerve excitability.
Brain 128:1841-1846.
6.
Krishnan A.V., Colebatch J.G., Kiernan M.C. (2005). Hypokalemic
weakness in hyperaldosteronism: activity-dependent conduction
block. Neurology 65:1309-12.
7.
Krishnan AV, Goldstein D, Friedlander M. Kiernan
MC.
(2005). Oxaliplatin-induced neurotoxicity and the
development of neuropathy. Muscle Nerve 32:51-60.
8.
Krishnan AV, Kiernan MC. (2005). Altered nerve excitability
properties in established diabetic neuropathy. Brain
128:1178-87.
9.
Krishnan, A.V., Lin, C.S., Kiernan, M.C. (2005). Excitability
differences in lower limb motor axons during and after ischemia.
Muscle Nerve 31:205-213.
10.
Krishnan A.V., Phoon R.K., Pussell B.A., Charlesworth J.A.,
Kiernan M.C. (2005). Altered motor nerve excitability in
end-stage kidney disease. Brain 128: 2164-2174.
11.
Winhammar JM, Rowe DB, Henderson RD, Kiernan MC. (2005).
Assessment of disease progression in motor neuron disease.
Lancet Neurology 4:229-238 (Invited review).
Book chapters
2005
1.
Kiernan, M.C., Burke, D. & Bostock, H. (2005). Nerve
excitability measures: biophysical basis and
use in the
investigation of peripheral nerve disease. In: Diseases of
the Peripheral Nervous System, Editors: P.J. Dyck and P.K
Thomas, Elsevier Saunders: Philadelphia, pages 113-129.
Key
Publications in 2006
1.
Kiernan MC (2006). Back to the future: excitability studies take
on a new clinical role. Clinical Neurophysiology
117:712-713. (Invited editorial).
2.
Kiernan M.C., Krishnan A.V. (2006). The pathophysiology of
oxaliplatin-induced neurotoxicity. Curr Med Chem 13:2901-2907.
(Invited review).
3.
Kiernan MC, Talman P, Henderson R, Harris R (2006).
Establishment of the Australian Motor Neurone Disease Registry.
Medical Journal of Australia 184:367-368.
4.
Krishnan A.V., Goldstein D, Friedlander M.
Kiernan MC.
(2006). Oxaliplatin and axonal Na+
channel function in vivo. Clinical Cancer Research (in
press).
5.
Krishnan AV, Kiernan MC. (2006). Axonal function and
activity-dependent excitability changes in myotonic dystrophy.
Muscle Nerve 2006 33:627-636.
6.
Krishnan A.V., Phoon R.K., Pussell B.A., Charlesworth J.A.,
Kiernan M.C. (2006). Sensory nerve excitability and neuropathy
in end-stage kidney disease. J. Neurol. Neurosurg. Psychiatry
77:548-551.
7.
Krishnan A.V., Phoon R.K., Pussell B.A., Charlesworth J.A.,
Bostock H., Kiernan M.C. (2006). Ischaemia induces paradoxical
changes in axonal excitability in end-stage kidney disease.
Brain (in press).
8.
Krishnan A.V., Phoon R.K., Pussell B.A., Charlesworth J.A.,
Bostock H., Kiernan M.C. (2006). Neuropathy, axonal Na+/K+
pump function and activity-dependent excitability changes in
end-stage kidney disease. Clinical Neurophysiology
117:992-999.
9.
Martin A., Friedlander M. Kiernan MC.
(2006).
Paraneoplastic mononeuritis multiplex in non-small-cell lung
carcinoma. Journal of Clinical Neuroscience (in press).
10.
McKay O., Krishnan A.V., Davies M., Kiernan M.C. (2006).
Activity-induced weakness in recessive myotonia congenita with a
novel mutation. Clinical Neurophysiology (in press).
11.
Nogajski JH, Engel S, Kiernan MC.
(2006). Focal
and generalised nerve dysfunction in spinal cord injured
patients. Journal of Clinical Neurophysiology (in press).
12.
Vucic S., Howells J., Trevillion L., Kiernan, M.C. (2006).
Assessment of cortical excitability using threshold tracking
techniques. Muscle Nerve 33:477-486.
13.
Vucic S., Kiernan, M.C. (2006). Axonal excitability properties
in amyotrophic lateral sclerosis. Clinical Neurophysiology
(in press).
14.
Vucic S., Kiernan, M.C. (2006). Novel threshold tracking
techniques suggest that cortical hyperexcitability is an early
feature of motor neurone disease. Brain (in press).
15.
Zoing M., Pamphlett R., Burke, D., Kiernan, M.C. (2006).
Riluzole therapy for motor neurone disease - an early Australian
experience (1996-2002). Journal of Clinical Neuroscience
13:78-83.
Book chapters 2006
1.
Burke, D. &
Kiernan, M.C. (2006). Developments in the assessment of
peripheral nerve function. In: Handbook of Clinical
Neurophysiology, Series Editors: J. Daube and F. Mauguière;
Clinical Neurophysiology of Peripheral Nerve Diseases,
edited by J. Kimura. Elsevier: Amsterdam, pages 935-951.
2.
Lin C.S., Kiernan, M.C., Burke, D. & Bostock, H. (2006). Nerve
excitability measures: biophysical basis and use in the
investigation of peripheral nerve disease. In: Handbook of
Clinical Neurophysiology, Series Editors: J. Daube and F.
Mauguière; Clinical Neurophysiology of Peripheral Nerve
Diseases, edited by J. Kimura. Elsevier: Amsterdam, pages
381-403.
Key Publications in 2007
1.
Krishnan A.V., Kiernan M.C. (2007). Uremic neuropathy: Clinical
features and new pathophysiological insights. Muscle Nerve
35:273-290. (Invited review).
2.
Boland RA, Krishnan A.V., Kiernan M.C. (2007). Riche-Cannieu
anastomosis as an inherited trait. Clinical Neurophysiology
118:770-775.
3.
Krishnan A.V., Hayes M., Kiernan M.C. (2007). Axonal
excitability properties in hemifacial spasm. Movement
Disorders (in press; 12/03/07).
4.
Lin CS, Macefield VG, Elam M, Wallin BG, Engel S, Kiernan M.C.
(2007). Axonal changes in spinal cord injured patients distal to
the site of injury. Brain [Epub Jan 30 ahead of print].
5.
Vucic S., Kiernan, M.C. (2007). Abnormalities in cortical and
peripheral excitability in cortical and peripheral excitability
in flail-arm variant amyotrophic lateral sclerosis. J.
Neurol. Neurosurg. Psychiatry [Epub Jan 10 ahead of print].
6.
Vucic S., Kiernan, M.C. (2007). Pathophysiological insights into
motor axonal function in spinobulbomuscular atrophy (Kennedy’s
disease). Neurology (provisional acceptance, 26/03/07).
7.
Vucic S., Krishnan A.V., Kiernan, M.C. (2007). Fatigue and
activity-dependent changes in axonal excitability in ALS. J.
Neurol. Neurosurg. Psychiatry [in press, 12/01/07].
Books 2007
Kiernan, M.C.
(editor). Handbook of Motor Neurone Disease. MJA books,
Australasian Medical Publishing Company, Sydney, 2007, 225 pages
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